Elefteria PsillakisClaudia E. DominiLorena VidalAntonio CanalsNuria Gran2024-10-312024-10-3120072015-09-24L.Vidal , C. E. Domini , N. Grane , E. Psillakis , A. Canals , "Microwave assisted headspace single-drop microextration of chlorobenzenes from water samples " ,Anal. Chim. Acta ,vol. 592 ,no. 1 ,pp.9–15.2007. doi:10.1016/j.aca.2007.03.066https://dspace.library.tuc.gr/handle/123456789/512Aone-step and in-situ sample preparation method used for quantifying chlorobenzene compounds inwater samples has been developed, coupling microwave and headspace single-drop microextraction (MW-HS-SDME). The chlorobenzenes in water samples were extracted directly onto an ionic liquid single-drop in headspace mode under the aid of microwave radiation. For optimization, a Plackett–Burman screening design was initially used, followed by a mixed-level factorial design. The factors considered were: drop volume, aqueous sample volume, stirring speed, ionic strength, extraction time, ionic liquid type, microwave power and length of the Y-shaped glass-tube. The optimum experimental conditions found from this statistical evaluation were: a 5 L microdrop of 1-hexyl-3-methylimidazolium hexafluorophosphate exposed for 20 min to the headspace of a 30mL aqueous sample, irradiated by microwaves at 200W and placed in a 50mL spherical flask connected to a 25 cm Y-shaped glass-tube. Under the optimised experimental conditions, the response of a high performance liquid chromatographic system was found to be linear over the range studied and with correlation coefficients ranging between 0.9995 and 0.9999. The method showed a good level of repeatability, with relative standard deviations varying between 2.3 and 8.3% (n = 5). Detection limits were found in the low gL−1 range varying between 0.016 and 0.039gL−1. Overall, the performance of the proposed method demonstrated the favourable effect of microwave sample irradiation upon HS-SDME. Finally, recovery studies from different types of environmental water samples revealed that matrix had little effect upon extraction8 pagesenhttp://creativecommons.org/licenses/by/4.0/Peer-Reviewed Journal Publication